Distinct Functions of POT1 in Telomere Protection and Length Regulation
نویسنده
چکیده
Distinct Functions of POT1 in Telomere Protection and Length Regulation by Katharine Specchio Barrientos Department of Pharmacology and Cancer Biology Duke University Date: November 20th, 2008 Approved: ___________________________ Christopher M. Counter, Ph.D., Supervisor ___________________________ Shawn Ahmed, Ph.D. ___________________________ Ann Marie Pendergast, Ph.D. ___________________________ Dennis Thiele, Ph.D. ___________________________ Xiao-Fan Wang, Ph.D. An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor in Philosophy in the Department of Pharmacology and Cancer Biology in the Graduate School of Duke University 2008 Copyright by Katharine Specchio Barrientos 2008
منابع مشابه
Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.
Protection of telomeres 1 (POT1) proteins in various organisms bind telomeres and regulate their structure and function. In contrast to mice carrying two distinct POT1 genes encoding two POT1 proteins (POT1a and POT1b), humans have the single POT1 gene. In addition to full-length POT1 protein (variant v1), the human POT1 gene encodes four other variants due to alternative RNA splicing (variants...
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